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Saffron (Affron®)

Saffron (Affron®) 

Overview
Affron® is a clinically studied saffron (Crocus sativus L.) extract standardized for its active compounds, crocin and safranal. Research has demonstrated its ability to support mood balance, emotional wellbeing, sleep quality, and relief from some menopausal symptoms. In clinical settings, Affron® is typically administered at a total daily dose of 28 mg, either as 14 mg twice daily or 28 mg once daily for 4 to 12 weeks.

Mood Support
Several double-blind, placebo-controlled studies have shown that Affron® helps improve mood and reduce feelings of stress and mild anxiety. In adults with low mood, a 4-week study using 28 mg/day demonstrated improved emotional balance and reduced negative mood states compared to placebo (Kell et al., Complementary Therapies in Medicine, 2017). In adolescents aged 12–16 with mild anxiety and depressive symptoms, an 8-week study using 14 mg twice daily found significant improvement in self-reported internalizing symptoms (Lopresti et al., Journal of Affective Disorders, 2018).

Sleep Quality
Affron® has been shown to promote restful sleep and improve overall sleep quality. In a 28-day randomized controlled trial, adults who consumed 14 mg or 28 mg of Affron® one hour before bedtime reported better sleep quality, increased melatonin levels, and improved morning mood compared to placebo (Lopresti et al., Sleep Medicine, 2021).

Menopausal Support
A 12-week clinical study in perimenopausal women demonstrated that 14 mg twice daily of Affron® significantly improved mood, reduced irritability, and alleviated feelings of anxiety and depression compared to placebo (Lopresti & Smith, Journal of Menopausal Medicine, 2021). These results highlight Affron® as a natural option for supporting emotional balance during the menopausal transition.

Mechanisms of Action
Saffron’s key bioactive compounds are believed to enhance serotonergic activity, increase antioxidant capacity, and modulate neuroendocrine pathways involved in mood, stress, and sleep regulation. These effects are attributed to the synergistic action of crocin, crocetin, picrocrocin, and safranal (Hosseinzadeh & Nassiri-Asl, Phytotherapy Research, 2013).

Safety and Tolerability
Across human clinical studies, Affron® has been shown to be well tolerated with no serious adverse events. Reported effects are mild and transient, typically including minor digestive discomfort at rates similar to placebo.

Conclusion
Affron® is a scientifically validated saffron extract that supports emotional wellbeing, sleep quality, and menopausal balance. Backed by multiple peer-reviewed clinical trials, it provides a safe and natural approach to maintaining mood and vitality through life’s transitions.

Key References

  • Kell, G., et al. (2017). Complementary Therapies in Medicine, 33, 58–64.

  • Lopresti, A. L., et al. (2018). Journal of Affective Disorders, 232, 349–357.

  • Lopresti, A. L., Smith, S. J. (2021). Journal of Menopausal Medicine, 27(2), 85–92.

  • Lopresti, A. L., et al. (2021). Sleep Medicine, 84, 362–369.

  • Hosseinzadeh, H., Nassiri-Asl, M. (2013). Phytotherapy Research, 27(5), 637–645.

Our Commitment to You

Quality & Transparency

At Chaly, transparency is more than a promise — it’s our process. From responsibly sourced ingredients to certified U.S. manufacturing and protective, recyclable packaging, every step is carefully controlled, documented, and verified. Our products are made in facilities that meet strict quality and safety standards, with full ingredient traceability and rigorous testing to ensure purity, consistency, and integrity in every batch.

At Chaly, transparency isn’t a marketing phrase — it’s a promise. Every product we create is manufactured in the United States in facilities that meet and exceed the highest safety and quality standards in the supplement industry.

Our manufacturing partner operates under current Good Manufacturing Practices (cGMP) for dietary supplements, ensuring strict control, consistency, and product integrity at every stage of production. Their advanced facilities include in-house analytical, quality assurance, and accredited microbiological laboratories, allowing for rigorous testing, verification, and safety monitoring throughout the manufacturing process.

This commitment to precision, safety, and accountability ensures that every product is produced with the care and standards your body deserves.

Our U.S.-based manufacturing facility maintain the following certifications:

- cGMP compliant to the Dietary Supplement Rule
- Certified Organic
- Kosher Certified
- Non-GMO Project Verified
- Fair for Life Certified
- SQF Level 2 Certified

At Chaly, transparency means knowing exactly what goes into your body — and where it comes from. Every ingredient in our formulas is fully traceable from raw source to finished product, ensuring purity, authenticity, and quality at every step.

Each batch of Chaly Vida Menopause Capsules is documented through a complete traceability system that tracks ingredient origin, supplier verification, and production records. This process ensures consistency, safety, and full accountability throughout manufacturing.

Key ingredients are sourced from trusted, quality-verified suppliers:

  • Organic Ashwagandha Root Extract (KSM-66®) — Ixoreal, USA
  • Maca Root Extract — AuNutra, USA
  • Fennel Seed Extract — AuNutra, USA
  • Saffron Stigma Extract (Affron®) — PharmActiv, Spain

Each ingredient undergoes identity, purity, and quality testing before production, and every finished batch is recorded and traceable for full transparency and safety assurance.

Chaly bottles are manufactured in the United States using high-quality, food-grade HDPE (High-Density Polyethylene)— a trusted material used in pharmaceutical and nutraceutical packaging for its strength, purity, and product protection.

Each container is produced under strict quality standards and inspected for structural integrity, cleanliness, and consistency to ensure your supplements remain safe, protected, and effective.

  • Material: Food-grade HDPE
  • Capacity: 225 cc
  • Neck Finish: 45-400 mm secure seal
  • Color: White, quality-verified
  • Made in: USA
  • Microbial Cleanliness Tested
  • Recyclable

Designed to protect product freshness while supporting responsible, sustainable packaging.

We have initiated Clean Label application. 

Clean Label Project™ is all about uncovering what product labels don’t tell you, so you can feel better about the things you use every day. Regular food safety checks often stop at bacteria and pathogens—but we dig deeper, looking for hidden stuff like heavy metals, pesticides, and plasticizers that most people never hear about.

Using real data and solid science, we’re raising the bar for product safety and recognizing brands that truly care about purity and transparency. If you want safer, cleaner products on the shelves, you choose for a Clean Label certified product. 

https://cleanlabelproject.org